创伤性脑损伤(traumatic brain injury,TBI)包括创伤部位的原发性脑损伤和创伤后的继发性脑损伤。TBI发生后数天至数个月内,继发性脑损伤仍在进行,且发生于细胞水平的继发性脑损伤可造成难以逆转的神经功能损害。脑组织缺血缺氧是继发性脑损伤的重要病理生理基础。改善TBI患者预后的关键在于抑制原发性脑损伤后的继发性缺血损伤。他汀类药物是羟甲基戊二酰辅酶A(hydroxymethylglutaryl coenzyme A,HMG-CoA)还 Traumatic brain injury (TBI) includes primary brain injury at the site of the trauma and secondary brain injury after the trauma. Secondary brain damage is still going on within a few days to several months after TBI, and secondary brain damage at the cellular level can cause irreversible neurological impairment. Ischemia and hypoxia of brain tissue is an important pathophysiological basis of secondary brain injury. The key to improving the prognosis of patients with TBI is to suppress secondary ischemic injury after primary brain injury. Statins are hydroxymethylglutaryl coenzyme A (HMG-CoA) also