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目的探讨米索前列醇片和萘普生栓用于人工流产术中的临床效果。方法将孕6～10周,无阴道分娩史,要求人工流产手术的健康妇女共240例随机分为A、B、C 3组各80例,A组:手术前2 h舌下含化米索前列醇片400μg,15 min前塞入肛门1粒萘普生栓(含萘普生0.4 mg);B组:用丙泊酚和芬太尼无痛人流;C组:不采取任何措施。观察3组镇痛效果、宫口松弛情况、人工流产综合征(RAAS)及阴道出血发生情况。结果 A组和B组镇痛总有效率和RAAS发生率明显低于C组(P<0.01,P<0.05);3组宫口松弛情况A组>B组>C组(P<0.01);阴道出血量B组明显高于A组和C组(P<0.01)。结论米索前列醇片和萘普生栓用于人工流产术镇痛效果好,宫弛好,RAAS发生率低,不增加阴道出血量,给药方便,安全,经济,值得推广。
Objective To investigate the clinical effect of misoprostol and naproxen on artificial abortion. Methods A total of 240 healthy women, aged 6 to 10 weeks with no history of vaginal delivery, were randomly divided into A group, B group and C group, with 80 cases in each group. Group A: Topical alcohol tablets 400μg, 15 minutes into the anus before the injection of a naproxen suppository (containing naproxen 0.4 mg); B group: with propofol and fentanyl painless; Group C: Without any measures. The analgesic effect, cervix relaxation, induced abortion syndrome (RAAS) and vaginal bleeding were observed. Results The total effective rate of RA and the incidence of RAAS in group A and group B were significantly lower than those in group C (P <0.01, P <0.05). The relaxation status of group 3 was significantly higher in group A than in group B (P <0.01). Vaginal bleeding in group B was significantly higher than those in groups A and C (P <0.01). Conclusion Misoprostol tablets and naproxen suppository are effective in analgesia induced by induced abortion, and have a good sagging rate and a low incidence of RAAS without increasing the amount of vaginal bleeding. Therefore, administration is convenient, safe and economical, which is worth promoting.