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目的 :观察环孢素治疗狼疮性肾炎的疗效。方法 :采用环孢素 5mg·kg- 1·d- 1,分 2～ 3次口服治疗 30例狼疮性肾炎 ,疗程 12wk。治疗前后观察病人临床表现 ,尿蛋白定量 ,肾功能及血清C3 ,C4 ,T细胞亚群 (CD4 + ,CD8+ ,CD4 + /CD8+ )等指标。结果 :环孢素治疗 12wk后 ,病人临床症状明显改善 ,尿蛋白为 0 .4 g·2 4h- 1±s0 .9g·2 4h- 1,较治疗前明显减少 (P <0 .0 1) ,肾功能 (BUN为 6 .4mmol·L- 1± 1.2mmol·L- 1,Scr为 136 μmol·L- 1± 91μmol·L- 1) ,较治疗前明显改善 (P <0 .0 1) ,血清C3 ,C4 及T细胞亚群 (CD4 + ,CD8+ ,CD4 + /CD8+ )与治疗前比较差异均有显著意义。结论 :环孢素对狼疮性肾炎治疗有效
Objective: To observe the curative effect of cyclosporine on lupus nephritis. Methods: Cyclosporine 5mg · kg-1 · d-1, 2 to 3 times oral treatment of 30 cases of lupus nephritis, treatment 12wk. The clinical manifestations, urine protein quantitation, renal function, serum C3, C4, T cell subsets (CD4 +, CD8 +, CD4 + / CD8 +) were observed before and after treatment. Results: After 12 weeks of cyclosporine treatment, the clinical symptoms of patients were significantly improved. The urinary protein was 0. 4 g · 2 4 h -1 ± s 0. 9 g · 2 4 h -1, which was significantly lower than that before treatment (P 0 01) , Renal function (BUN was 6.4 mmol·L -1 ± 1.2 mmol·L -1, Scr was 136 μmol·L -1 ± 91 μmol·L -1), which was significantly improved compared with those before treatment (P0.01) , Serum C3, C4 and T cell subsets (CD4 +, CD8 +, CD4 + / CD8 +) were significantly different from those before treatment. Conclusion: Cyclosporine is effective in the treatment of lupus nephritis