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目的:探讨女性强直性脊柱炎患者的临床特点。方法:回顾性分析华西医院风湿免疫科2003年1月1日至2009年1月1日住院收治的女性强直性脊柱炎患者住院病历共计46例,抽取与女性患者入院时间及病程大致相等的男性病历40例,记录发病年龄、病程、首发症状、临床表现、实验室检查,并对两组数据进行比较,调查女性患者中血小板计数与血沉、C-反应蛋白、球蛋白的相互关系。结果:发病年龄女性组为(30±11)岁,男性组为(24±7)岁(P=0.003);首发症状、主要临床表现、关节活动受限和病情活动指标在两组无统计学差异(P>0.05)。相关分析显示,血小板计数与C-反应蛋白、血沉、球蛋白分别存在较好的正相关关系(C-反应蛋白:r=0.608,P=0.000;血沉:r=0.558,P=0.000;球蛋白r=0.411,P=0.005)。女性组中HLA-B27阳性患者与阴性患者的年龄差异无统计学意义(P>0.05)。结论:女性强直性脊柱患者的发病年龄大于男性,患者的血小板计数有助于评价病情活动。
Objective: To investigate the clinical features of female patients with ankylosing spondylitis. Methods: Retrospective analysis of 46 cases of hospitalized patients with rheumatoid arthritis of West China Hospital from January 1, 2003 to January 1, 2009 admitted to hospital for treatment of ankylosing spondylitis in women with approximately the same time and course of admission as the female patients 40 cases were recorded, the age of onset, course of disease, initial symptoms, clinical manifestations, laboratory tests were recorded. The data of two groups were compared to investigate the correlation between platelet count and ESR, C-reactive protein and globulin in female patients. Results: The onset age was (30 ± 11) years in the female group and (24 ± 7) years in the male group (P = 0.003). The first symptom, the main clinical manifestations, the limited joint activity and the index of the disease activity were not statistically significant between the two groups Difference (P> 0.05). Correlation analysis showed that there was a positive correlation between platelet count and C-reactive protein, erythrocyte sedimentation rate and globin (C-reactive protein: r = 0.608, P = 0.000; erythrocyte sedimentation rate: r = 0.558, r = 0.411, P = 0.005). There was no significant difference in the age of HLA-B27 positive patients and negative patients among the female patients (P> 0.05). CONCLUSIONS: The age at onset of ankylosing spine in women is greater than that of men and the platelet count of patients contributes to the evaluation of disease activity.