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A novel method for the determination of two quinolone drugs norfloxacin(NOR)and levofloxacin(LVX)was described by capillary electrophoresis with electrochemiluminescence detection.The good relationship(r≥0.9991)between peak area and concentration of analytes was established over two orders of magnitude.The limits of detection(LOD,S/N=3)in standard solution are 4.8×10~(-7)mol/L for NOR and 6.4×10~(-7)mol/L for LVX,respectively.The limits of quantitation(LOQ,S/N=10)in real human urine samples are 1.2×10~(-6)mol/L for NOR and 1.4×10~(-6)mol/L for LVX,respectively.The present method was successfully applied to the determination of NOR and LVX in human urine and the study of pharmacokinetics of NOR.
A novel method for the determination of two quinolone drugs norfloxacin (NOR) and levofloxacin (LVX) was described by capillary electrophoresis with electrochemiluminescence detection. Good relationship (r ≧ 0.9991) between peak area and concentration of analytes was established over two orders of magnitude The limits of detection (LOD, S / N = 3) in standard solution are 4.8 × 10 -7 mol / L for NOR and 6.4 × 10 -7 mol / L for LVX, respectively. of quantitation (LOQ, S / N = 10) in real human urine samples are 1.2 × 10 -6 mol / L for NOR and 1.4 × 10 -6 mol / L for LVX, respectively.The present method was successfully applied to the determination of NOR and LVX in human urine and the study of pharmacokinetics of NOR.