吲■酰胺在六十年代首先由法国提出,经大量研究后,已在法国、西德、意大利、美国、日本等国广泛应用于临床,并在国际上受到普遍的重视。吲(?)酰胺的药理作用主要是抑制血管平滑肌细胞的内向钙离子流,降低血管收缩及血管对升压物质的反应性,从而使周围阻力下降而产生降压效果。此药降压效应较强,大剂量有利尿作用,小剂量利尿作用甚微,对神经、呼吸、消化等系统无不良作用,对血 Amide was first proposed by France in the 1960s. After extensive research, it has been widely used in clinical practice in France, West Germany, Italy, the United States, Japan and other countries, and has received widespread international attention. The pharmacological effects of indole (?) Amide are mainly to inhibit the inward calcium flux in vascular smooth muscle cells, reduce vasoconstriction and the reactivity of blood vessels to the vasopressors, so as to reduce the peripheral resistance and produce antihypertensive effects. The antihypertensive effect of this drug is strong, high-dose diuretic effect, small doses of diuretic effect is very small, no adverse effects on the nervous, respiratory, digestive system, blood