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目的:探讨环氧合酶-2(COX-2)选择性抑制剂在食管癌放疗中的增敏作用。方法:将59例经病理确诊的食管癌病人随机分为两组(治疗组29例、对照组30例),两组采用相同的放射野、放射总量和分割剂量,治疗组在放疗同时给予COX-2选择性抑制剂塞来昔布,对照组采用单纯放疗。采用肿瘤局部控制率(CR+PR)作为疗效的评价标准。结果:治疗组在放疗60Gy时的有效率较对照组明显提高(82.8%比63.3%,P<0.05)。结论:COX-2选择性抑制剂对食管癌放疗具有显著的增敏作用,副作用较小、安全、有效。
Objective: To investigate the sensitizing effect of selective cyclooxygenase-2 (COX-2) inhibitor in radiotherapy of esophageal cancer. Methods: 59 cases of pathologically diagnosed esophageal cancer patients were randomly divided into two groups (29 cases in the treatment group and 30 cases in the control group). The two groups were treated with the same radiation field, total radiation dose and divided dose. The patients in the treatment group were treated with radiotherapy COX-2 selective inhibitor celecoxib, the control group with radiotherapy alone. Tumor local control rate (CR + PR) as the evaluation criteria for efficacy. Results: The effective rate of radiotherapy 60Gy in treatment group was significantly higher than that in control group (82.8% vs. 63.3%, P <0.05). CONCLUSION: COX-2 selective inhibitors have significant sensitizing effect on radiotherapy of esophageal cancer with less side effects, which is safe and effective.