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目的制备包封率较高且具有较好缓释性能的盐酸青藤碱多囊脂质体。方法用复乳法制备盐酸青藤碱多囊脂质体,以包封率和囊形为考察指标,采用均匀设计优选最佳处方和工艺,并考察其形状、粒径及体外释放性能。结果制得的盐酸青藤碱多囊脂质体包封率在80%以上,形状圆整,粒径较均匀,多数分布在20～30μm,体外释放符合Higuchi方程,释药t1/2为52.7 h。结论盐酸青藤碱多囊脂质体处方工艺稳定可行,包封率高且具有良好的缓释特性。
Objective To prepare sinomenine hydrochloride multivesicular liposomes with high entrapment efficiency and better sustained release properties. Methods The sinomenine hydrochloride multivesicular liposome was prepared by the double emulsion method. The encapsulation efficiency and capsule shape were used as indicators. Uniform design was used to optimize the best formulation and process, and its shape, size, and in vitro release properties were investigated. As a result, the entrapment efficiency of sinomenine hydrochloride multivesicular liposome prepared was more than 80%, and the shape was round and the particle size was relatively uniform. Most of them were distributed at 20-30 μm. The in vitro release was consistent with the Higuchi equation, and the drug release t1/2 was 52.7. h. Conclusion The formulation of sinomenine hydrochloride multivesicular liposome is stable and feasible, with high encapsulation efficiency and good sustained-release characteristics.