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目的探讨奥硝唑治疗滴虫性阴道炎患者的临床疗效及对细胞因子变化的影响。方法选取2012年10月至2014年10月收治的60例滴虫性阴道炎患者资料,按随机数字表法将其分为奥硝唑组与甲硝唑组,各30例,分别使用奥硝唑与甲硝唑治疗。比较两组患者的临床疗效及细胞因子的变化情况。结果奥硝唑组患者总有效率为93.3%,明显高于甲硝唑组的70.0%,且镜检结果表明奥硝唑组患者治疗后阴道分泌物中滴虫数明显低于甲硝唑组,差异均有统计学意义(均P<0.05);治疗后,两组患者阴道分泌液中的IL-2、IL-8、IL-13水平均明显降低,奥硝唑组患者治疗后的IL-8及IL-13水平的变化值均明显高于甲硝唑组,差异均有统计学意义(均P<0.05)。结论采用奥硝唑治疗滴虫性阴道炎临床疗效明显,可有效降低阴道分泌物中细胞因子的水平。
Objective To investigate the clinical efficacy of ornidazole in the treatment of trichomonas vaginitis and its influence on the changes of cytokines. Methods The data of 60 cases of trichomonas vaginitis admitted from October 2012 to October 2014 were divided into ornidazole group and metronidazole group according to random number table method, Azole and metronidazole treatment. The clinical efficacy and changes of cytokines in two groups were compared. Results The total effective rate of the ornidazole group was 93.3%, which was significantly higher than that of the metronidazole group (70.0%). The results of microscopic examination showed that the number of trichomoniasis in the vaginal secretions of the patients treated with ornidazole was significantly lower than that of the metronidazole group (All P <0.05). After treatment, the levels of IL-2, IL-8 and IL-13 in the vaginal fluid of the two groups were significantly decreased, and the levels of IL -8 and IL-13 levels were significantly higher than the metronidazole group, the difference was statistically significant (P <0.05). Conclusion Ornidazole treatment of trichomonas vaginitis clinical curative effect is obvious, can effectively reduce the level of cytokines in vaginal secretions.