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氨苄青霉素自1961年投入临床使用后,迄今已成为治疗多种感染的首选抗生素。氨苄青霉素的各种酯如匹氨青霉素(pivampicillin)、氨苄青霉素碳酯(bacampicillin)、酞氨苄青霉素(talampicillin)及有关化合物或氨苄青霉素类似物如环青霉素(ciclacillin)、依比青霉素(epicillin)、羟氨苄青霉素(amoxycillin)亦相继出现,但这些制剂是否真的优于氨苄青霉素呢?3种氨苄青霉素酯从肠道吸收后,被水解成氨苄青霉素,故其抗菌活性与氨苄青霉素完全相同。依比青霉素的抗菌谱及抗菌活
Ampicillin since its inception in 1961, has so far become the preferred antibiotic for the treatment of multiple infections. Various esters of ampicillin such as pivampicillin, bacampicillin, talampicillin and related compounds or ampicillin analogs such as ciclacillin, epicillin, Amoxycillin also appeared one after another, but are these preparations really superior to ampicillin? The three ampicillin esters are hydrolyzed to ampicillin after being absorbed from the intestine, so their antibacterial activity is exactly the same as that of ampicillin. Antibacterial spectrum and antimicrobial activity than penicillin