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采用放射免疫分析法观察95例老年男性骨质疏松患者应用珍牡胶囊和霜叶红治疗前后骨代谢指标的含量变化。结果显示 ,与30例正常人比较 ,患有不同程度骨质疏松的老年男性组血清25 -OH -D水平明显降低(t=7.72;P<0.01) ,服药后明显高于服药前(t=6.64;P<0.01)。PTH含量在服药前高于对照组(t=9.55;P<0.01)。服药后PHT含量明显下降 ,与服药前比较差异显著(t=6.87;P<0.01)。服药前骨密度测定值0.601±0.036 ,下降百分率为27.6±5.1 ,服药后测定值0.678±0.045下降百分率为25.0±3.6。提示老年男性骨质疏松的发生与25 -OH -D减少、PTH -M增加有关。珍牡胶囊与霜叶红联用能有效地防治骨量丢失和老年骨质疏松症。
Radioimmunoassay was used to observe the changes of bone metabolism indexes in 95 elderly men with osteoporosis before and after treatment with Zhenmu capsule and Shuyeyehong. The results showed that the level of serum 25-OH-D was significantly lower in elderly men with different degrees of osteoporosis (t = 7.72; P <0.01) compared with those in 30 normal subjects, 6.64; P <0.01). PTH levels in the medication before the control group (t = 9.55; P <0.01). After taking the drug, the content of PHT decreased significantly compared with before treatment (t = 6.87; P <0.01). Before taking medicine, the measured value of bone mineral density was 0.601 ± 0.036, the percentage decrease was 27.6 ± 5.1, the percentage decrease after taking medicine was 0.678 ± 0.045 was 25.0 ± 3.6. Prompted the incidence of osteoporosis in elderly men with 25-OH-D decreased PTH-M increased. Zhenmu capsules and cream Ye Hong can effectively prevent and treat bone loss and osteoporosis in the elderly.