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目的：了解2011－2013年某医院血液标本中检出常见病原菌的分布及药物敏感情况。方法采用美国BD公司血培养仪和法国梅里埃公司血培养仪培养，VITEK-2 Compact全自动细菌鉴定仪进行鉴定及药敏试验。结果2011－2013年共分离出950株病原菌，以革兰阴性菌为主；大肠埃希菌检出率较高，3年分别占41．9％、28．6％、27．3％，其中产超广谱β－内酰胺酶（ESBLs）占43．8％～60．8％。2013年凝固酶阴性葡萄球菌占20．1％。2011－2013年耐甲氧西林金黄色葡萄球菌的检出率分别为13．3％、33．3％和43．2％，耐甲氧西林的凝固酶阴性葡萄球菌的检出率分别为50．0％、76．9％和86．1％。结论血液标本检出病原菌的分布及耐药有显著变化，临床应根据血液培养结果合理用药。“,”Objective To understand the distribution and drug resistance of common pathogenic bacteria which cultured from blood specimens in the past 3 years. Methods Pathogens were cultured using BD blood culture systems and French Merieux blood culture system. VITEK-2 Compact automatic bacterial identification instrument was used for identification and drug sensitivity test of the isolated pathogens. Results In the past 3 years, there were 950 isolated pathogenic bacteria, mainly gram-negative bacteria. In the years 2011-2013, the culture rates of Escherichia coli were 41.9%, 28.6%, and 27.3%, respectively. In which, the isolation rate of extended-spectrumβ-lactamases (ESBLs) was 43.8%~60.8%. In 2013, the culture rate of coagulase negative staphylococci was 20.1%. From 2011 to 2013 , the isolation rates of methicillin-resistant Staphylococcus aureus were 13.3%, 33.3%and 43.2%, respectively, for methicillin-resistant coagulase-negative staphylococci were 50.0%, 76.9%and 86.1%, respectively. Conclusion Distribution and antibiotic resistance of pathogenic bacteria cultured from blood specimens have a significant change in the past 3 years. Clinician should use the antibiotics reasonably according to the result of blood culture.