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目的评价角膜缘干细胞移植术治疗翼状胬肉的疗效。方法通过对单纯翼状胬肉切除术与翼状胬肉角膜缘干细胞移植术分析比较评价疗效。将106例(118眼)翼状胬肉患者随机分成A,B两组:A组50例(59眼)行翼状胬肉角膜缘干细胞移植术,B组56例(59眼)行单纯翼状胬肉切除术。术后1周,1个月及3个月,观察比较两组患者球结膜充血状况及角膜上皮愈合时间和术后2年翼状胬肉复发情况。结果在术后1周,1个月及3个月,球结膜充血持续时间比较及角膜上皮愈合时间比较,两组差异均有统计学意义(P<0.05)。术后2年A组2例(2眼)复发,复发率为3.45%,B组8例(10只眼)复发,复发率为13.3%,两组比较差异有统计学意义(P<0.05)。结论翼状胬肉角膜缘干细胞移植术与单纯翼状胬肉切除术比较具有术后恢复快,手术复发率低等优点。
Objective To evaluate the efficacy of limbal stem cell transplantation in the treatment of pterygium. Methods The efficacy of simple pterygium excision and pterygium limbal stem cell transplantation were compared and evaluated. A total of 106 patients (118 eyes) with pterygium were randomly divided into two groups: group A (50 eyes, 59 eyes), limbal stem cell transplantation (Pterygium), group B, 56 patients (59 eyes) with simple pterygium cut. One week, one month and three months after operation, the conjunctival hyperemia and healing time of corneal epithelium and recurrence of pterygium 2 years postoperatively were observed and compared. Results The duration of conjunctival hyperemia and the healing time of corneal epithelium at 1 week, 1 month and 3 months after operation were significantly different between the two groups (P <0.05). The recurrence rate was 3.45% in 2 cases (2 eyes) in group A and 8 cases (10 eyes) in group B, the recurrence rate was 13.3% in 2 years after operation. The difference between the two groups was statistically significant (P <0.05) . Conclusion Pterygium limbal stem cell transplantation compared with simple pterygium excision has the advantages of fast recovery and low recurrence rate.