Objective:To explore the effectiveness and safety of cardiac rehabilitation qigong exercise in stable coronary artery disease (CAD) patients undergoing phase Ⅲ rehabilitation.Methods:This was a randomized controlled trial.A total of 59 stable CAD patients undergoing phase Ⅲ rehabilitation treated in Sports Medicine Hospital from March 2017 to September 2017 were enrolled after meeting the inclusion criteria and then divided into cardiac rehabilitation qigong exercise group (n =30) receiving a 12-week intervention and control group (n =29).All participants were assessed at baseline and at 12-week intervention for the primary outcome,that was treadmill test parameter and the secondary outcomes including physical fitness,body composition,bone mineral density,and cardiac ultrasound B-mode imaging.Results:There were no significant differences in baseline demographics between the two groups.After a 12-week cardiac rehabilitation qigong exercise intervention,compared with the control group,ΔV02 (initial 1352.63 ± 340.95 vs 12 weeks 1594.57 ± 467.14) vs (initial 1363.83 ± 322.90 vs 12 weeks 1323.76 ± 318.92) (P =.003),ΔVO2/kg (initial 21.23 ± 3.56 vs 12 weeks 24.75 ± 5.11) vs (initial 21.01 ± 3.71 vs 12 weeks 20.35 ± 3.66) (P =.002),ΔMETS (initial 6.19 ± 1.12 vs 12 weeks 7.16 ± 1.60) vs (initial 6.00 ± 1.19 vs 12 weeks 5.86 ± 1.23) (P =.001),ΔVO2/HR (P =.027),ΔSV (P =.014),ΔOUES (P =.012),Δhand-grip strength (P =.002),Δflexibility (P =.001),Δbalance (P =.002),ΔT-score (P =.042),ΔBQI (P =.018).However,Δresting systolic blood pressure (P =.004) and Δresting diastolic pressure (P =.012) decreased in the cardiac rehabilitation qigong exercise group.Conclusion:Cardiac rehabilitation qigong exercise can improve cardiopulmonary aerobic capacity,physical fitness,bone mineral density in patients with stable CAD,suggesting that certain effect and safety for stable CAD patients undergoing phase Ⅲ rehabilitation can be obtained.