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本实验在于阐明频域心电图(FCG)可以反映冠状动脉血流量(CBF)。狗的冠状动脉(CA)左前降支予以轻度狭窄,R_x、R_(xy)、F_(min)值都增大,说明FCG这些参数的变化比由CA左旋支狭窄引起的变化提前出现(左旋支在中度狭窄时才出现FCG的变化)。当狭窄程度达到中度或重度时,除了R_y在中度狭窄不发生明显变化外,其余指标都显著增大(p<0.05),F_(min)和R_(xy)增大程度尤其明显(p<0.01),心率(HR)和CBF显著下降,主动脉平均压(P_a)轻度下降。 在CBF减少的情况下,通过CA灌注硝酸甘油(8μg/min)10min后,HR、CBF、R_x、R_y、R_(xy),和F_(min)没有明显变化,而小冠状动脉远端平均压(P_c)降低(p<0.01),p_x、P_y也降低(p<0.05)。在相同情况下,灌注烟浪丁,HR和P_a几乎不变,P_c和CBF明显上升;除F_(min)外,FCG所有的指标都增大(p<0.05)。在CA狭窄的情况下,麦角新碱可诱发血管收缩,反映在P_a、HR和CBF轻度下降和P_c、P_x、P_y、R_x、F_(min)、R_y和R_(xy)显著上升,CA灌注麦角新碱(0.2μg/min)后,FCG的指标随着缺血程度的改变而变化。
This experiment is to clarify that frequency-domain electrocardiography (FCG) can reflect coronary blood flow (CBF). The left anterior descending branch of the coronary artery (CA) of dogs was mild stenosis, and the values of R_x, R_ (xy) and F_ (min) increased, indicating that the changes of FCG were earlier than those caused by left circumflex coronary artery stenosis Branch in the narrow when there FCG changes). When the degree of stenosis reached moderate or severe, except R_y did not change obviously in moderate stenosis, the other indexes were significantly increased (p <0.05), especially the increase of F_ (min) and R_ (xy) (p <0.01), heart rate (HR) and CBF decreased significantly, aortic mean pressure (P_a) decreased slightly. In the absence of CBF, there was no significant change in HR, CBF, R_x, R_y, R_ (xy), and F_ (min) after perfusion of nitroglycerin (8 μg / min) (P_c) decreased (p <0.01), p_x, P_y also decreased (p <0.05). Under the same conditions, the perfusion of puff, HR and P_a almost did not change, and the P_c and CBF increased obviously. All the indexes of FCG except F_ (min) increased (p <0.05). In the case of CA narrowing, ergometrine induced vasoconstriction, which was reflected in mild decrease of P_a, HR and CBF and significant increase of P_c, P_x, P_y, R_x, F_ (min), R_y and R_ (xy) Ergometrine (0.2μg / min), FCG indicators with the degree of ischemia changes.