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万古霉素是由S·Qrientalis的培养滤液中分离提取的糖肽类抗生素,它以高度的亲和力与细胞壁的前体结构结合,抑制敏感菌细胞壁的合成,对菌体细胞膜也有损害作用,可改变细胞膜通透性,还能选择性抑制核糖核酸的合成,为繁殖期杀菌剂。万古霉素对革兰氏阳性细菌,如葡萄球菌(包括耐青霉素菌株)、溶血性链球菌、肠球菌、肺炎球菌、草绿色链球菌、白喉杆菌、梭状芽胞杆菌具有迅速、强大的杀菌作用,最低抑菌浓度为0.1～2μg/ml。细菌对万古霉素不易产生耐药性,而且与其它抗生素不产生交叉耐药性是该药的优点。临床上除伪膜性肠炎可作首选药物外,通常作为二线抗生素,主要用于对青霉素或半合成青霉
Vancomycin is a glycopeptide antibiotic extracted and isolated from culture filtrate of S · Qrientalis, which binds to the cell wall precursor structure with high affinity, inhibits the synthesis of sensitive cell wall, and can also damage the cell membrane of bacteria Cell membrane permeability, but also selectively inhibit ribonucleic acid synthesis, for the breeding season fungicide. Vancomycin has a rapid and powerful bactericidal effect against Gram-positive bacteria such as staphylococci (including penicillin-resistant strains), hemolytic streptococci, enterococci, pneumococci, Streptococcus viridae, diphtheria bacillus, Clostridium , The minimum inhibitory concentration of 0.1 ~ 2μg / ml. Bacteria are not prone to vancomycin resistance, and other antibiotics do not produce cross-resistance is the drug’s advantages. In addition to clinical pseudomembranous colitis can be the first choice for drugs, usually as a second-line antibiotics, mainly for penicillin or semi-synthetic Penicillium