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目的:检测胎盘早剥、重度子痫前期及正常妊娠孕妇的血清CA125、甲胎蛋白和胎盘生长因子水平,探讨其与胎盘早剥的关系,为胎盘早剥的预测及早期诊断提供理论依据。方法:采用微粒酶免疫分析法(MEIA)和双抗体夹心ELISA法检测孕妇血清CA125、甲胎蛋白和胎盘生长因子水平。结果:胎盘早剥组CA125和甲胎蛋白明显高于其他两组,胎盘生长因子明显低于其他两组(P<0.05)。结论:检测外周血CA125、甲胎蛋白和胎盘生长因子水平对于预测胎盘早剥具有一定的临床价值。
Objective: To detect the levels of serum CA125, alpha-fetoprotein and placental growth factor in placental abruption, severe preeclampsia and normal pregnant women and to explore their relationship with placental abruption, providing a theoretical basis for the prediction and early diagnosis of placental abruption. Methods: Serum CA125, alpha-fetoprotein and placental growth factor were detected by MEIA and double antibody sandwich ELISA. Results: CA125 and alpha-fetoprotein in placental abruption group were significantly higher than the other two groups, placental growth factor was significantly lower than the other two groups (P <0.05). Conclusion: The detection of peripheral blood CA125, α-fetoprotein and placental growth factor level has some clinical value for predicting placental abruption.