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目的观察分析阿昔洛韦联合纳洛酮治疗病毒性脑炎的临床疗效。方法将我院2014年5月至2015年5月收治的96例病毒性脑炎患儿分为观察组和对照组各48例,对照组患儿给予阿昔洛韦治疗,观察组患儿给予纳洛酮联合阿昔洛韦治疗,比较两组患儿临床疗效,分析对血清SNE、S-100β、MMP水平的影响,随访1年,记录后遗症。结果观察组总有效率高于对照组(P<0.05);观察组治疗后NSE、S-100β、MMP水平改善优于对照组(P<0.05);观察组后遗症发生率低于对照组(P<0.05)。结论针对病毒性脑炎患儿,改用阿昔洛韦联合纳洛酮治疗效果显著,减少后遗症,可在临床推广。
Objective To observe and analyze the clinical efficacy of acyclovir and naloxone in the treatment of viral encephalitis. Methods 96 cases of viral encephalitis admitted to our hospital from May 2014 to May 2015 were divided into observation group and control group, 48 cases in each group. The control group was treated with acyclovir and the observation group was given Naloxone combined with acyclovir, the clinical efficacy of two groups were compared, the impact of serum SNE, S-100β, MMP levels were analyzed, followed up for 1 year, recorded sequelae. Results The total effective rate in the observation group was higher than that in the control group (P <0.05). The improvement of NSE, S-100β and MMP in the observation group was better than that in the control group (P <0.05). The incidence of sequelae in the observation group was lower than that in the control group <0.05). Conclusion For children with viral encephalitis, the use of acyclovir combined with naloxone is effective in reducing sequelae and can be clinically promoted.