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目的对宫颈癌新辅助化疗后手术切除组织病理学变化进行观察对比。方法 58例宫颈癌患者,在采取新辅助化疗后均行手术切除术治疗,治疗后,对组织病理学变化情况和临床治疗效果进行观察分析。结果患者治疗总有效率为89.7%,治疗后患者的肿瘤平均直径明显短于治疗前,差异有统计学意义(P<0.05);血管内皮生长因子(VEGF)阳性率明显低于治疗前(P<0.05)。结论宫颈癌患者新辅助化疗后行手术切除术治疗,能够使组织病理学明显改变,并显著增强疗效,提高治愈率,值得临床推广。
Objective To compare the histopathological changes after neoadjuvant chemotherapy for cervical cancer. Methods Fifty-eight patients with cervical cancer underwent neoadjuvant chemotherapy after operation. After treatment, the histopathological changes and clinical effects were observed and analyzed. Results The total effective rate of treatment was 89.7%. After treatment, the mean tumor diameter was significantly shorter than before treatment (P <0.05). The positive rate of VEGF was significantly lower than that before treatment (P <0.05). Conclusion Cervical cancer patients undergoing neoadjuvant chemotherapy after surgical resection can significantly change the histopathology, and significantly enhance the efficacy and improve the cure rate, it is worth clinical promotion.