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目的 了解急性脑血管病 (ACVD)患者血浆D 二聚体 (D dimer)含量的变化 ,为进一步研究ACVD的病理生理机制、病程判定及疗效观察提供试验依据。方法 对 68例ACVD患者和 3 1例正常人用酶联免疫吸附试验(ELISA)双抗体夹心法检测血浆D 二聚体的含量。结果 急性期ACVD较正常人的D 二聚体含量明显升高 ,恢复期下降 ,急性期和恢复期比较有显著差异 ,而脑出血 (CH)急性期和脑梗死 (CI)急性期两组间比较D 二聚体的差异不显著。结论 提示CH和CI是高凝状态的两种不同表现 ,即使是CH也不是原发或继发的纤溶亢进所致 ,而是高凝造成的血管硬化破裂所致 ,血浆D 二聚体的检测可作为ACVD病程判定疗效观察的有用指标
Objective To investigate the changes of plasma D dimer in patients with acute cerebrovascular disease (ACVD) and provide experimental basis for further study on the pathophysiological mechanism, course of disease judgment and curative effect observation of ACVD. Methods Sixty-eight patients with ACVD and thirty-one normal controls were tested for D-dimer by enzyme-linked immunosorbent assay (ELISA) double antibody sandwich method. Results Compared with normal subjects, ACVD in acute phase showed a significant increase in D dimer and a decrease in convalescence. There were significant differences between acute phase and convalescent phase. However, acute phase of cerebral hemorrhage (CH) and acute phase of cerebral infarction The difference between D dimers was not significant. The results suggest that CH and CI are two different manifestations of hypercoagulable state, even if CH is not caused by primary or secondary fibrinolysis, but due to the hardening of the blood vessels caused by rupture of the blood, the plasma D-dimer Detection can be used as a useful indicator of the course of ACVD to determine the efficacy of observation