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我室于1965年首次应用亚硒酸钠预防克山病取得初步效果以来,至今全国由东北到西南十个省(区)六十九个县试用了硒预防克山病,服硒人数达142万人次。1979年5月,由中共中央北方防治地方病领导小组办公室,在西安主持召开了“口服亚硒酸钠预防克山病效果”鉴定会,会上肯定了硒预防该病急发的效果。目前全国对硒的研究,已作过大量的内外环境中硒的调查及动物实验等基础工作,取得了大量的数据。现在可以说;我国由东北到西南向这一宽的克山病病区,是一个低硒地带。低硒是克山病的一个基本因素。但硒为什么能够预防该病的急发?硒预防是病因学或是发病学的关系?是急待解决的问题。国外曾观察到大白鼠食饵性肝坏死的潜伏期,肝切片在体外不能维持正常呼吸,所谓呼吸衰竭(Respi-
My room in 1965, the first application of sodium selenite to prevent Keshan disease achieved initial results, so far the country from northeast to southwest 10 provinces (districts) 69 counties tried to prevent Keshan disease selenium up to 142 Million times. In May 1979, the Office of the Leading Group for Prevention and Treatment of Endemic Diseases in the North of the Central Committee of the Communist Party of China held an appraisal meeting on the effect of oral sodium selenite against Keshan disease in Xi’an, at which the effect of selenium in preventing the rapid onset of the disease was affirmed. At present, researches on selenium have made a great deal of basic work such as selenium investigation and animal experiments in both domestic and foreign environments, and a great deal of data have been obtained. Now it can be said that our wide-ranging Keshan disease area from northeast to southwest is a low-selenium zone. Selenium is a low essential element of Keshan disease. But why selenium can prevent the rapid development of the disease? Selenium prevention is the relationship between etiology or pathogenesis? It is an urgent problem to be solved. Abroad has observed the latency of rat induced by hepatic necrosis, liver slices can not maintain normal breathing in vitro, the so-called respiratory failure (Respi-