本室以往的研究发现硫酸乙酰肝素蛋白聚糖对培养的胎儿主动脉平滑肌细胞的增殖有明显的抑制作用。本实验采用Ｎｏｒｔｈｅｒｎｂｌｏｔ的方法观察硫酸乙酰肝素蛋白聚糖对胎儿主动脉平滑肌细胞的ｃ－ｆｏｓ，ｃ－ｍｙｃ原癌基因的表达的影响，发现前者能抑制后者的表达。因此硫酸乙酰肝素蛋白聚糖抑制平滑肌细胞增殖的途径之一可能为抑制原癌基因的表达。 Our previous study found that heparan sulfate proteoglycans significantly inhibited the proliferation of cultured fetal aortic smooth muscle cells. In this study, the effect of heparan sulfate proteoglycan on the expression of c-fos, c-myc proto-oncogene in fetal rat aortic smooth muscle cells was observed by Northern blotting and found that the former can inhibit the expression of the latter. Therefore, one of the ways of inhibiting the proliferation of smooth muscle cells by heparan sulfate proteoglycan may be to inhibit the expression of protooncogene.