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IL-6是一种多效性前炎症细胞因子,具有多种生物学活性,包括介导炎症反应、免疫反应等。随着对IL-6及其受体信号通路研究的不断深入,IL-6现已成为一个有效的治疗靶点,在炎症及自身免疫性疾病的治疗过程中发挥重要作用。采用文献调研、数据库检索、数据统计与分析等定性定量情报学研究方法,从研发阶段、适应证、临床及上市药物等方面对全球IL-6靶标药物的研发情况进行分析,旨在为我国免疫药物的研发提供参考。
IL-6 is a pleiotropic pro-inflammatory cytokine that has a variety of biological activities including mediating inflammatory and immune responses. With the continuous research of IL-6 and its receptor signaling pathways, IL-6 has become an effective therapeutic target and plays an important role in the treatment of inflammatory and autoimmune diseases. The research situation of IL-6 target drugs in the world was analyzed from the aspects of research and development phase, indications, clinical and marketed drugs and so on. Drug research and development provide a reference.