系统性红斑狼疮（systemiclupuserythematosus，SLE）是一种累及多系统、多脏器的自身免疫性疾病。其发病机制复杂，治疗难度大。传统的治疗方法通常是采用皮质类固醇与环磷酰胺和硫唑嘌呤等免疫抑制剂联合。虽然对病情的控制有一定的作用，但增加了感染、骨髓抑制和发生恶性肿 Systemic lupus erythematosus (systemic lupus erythematosus, SLE) is a multi-system, multi-organ involved in autoimmune diseases. The pathogenesis is complex, difficult to treat. The traditional treatment is usually the combination of corticosteroids and immunosuppressants such as cyclophosphamide and azathioprine. Although the control of the disease have a role, but increased infection, bone marrow suppression and the occurrence of malignant