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目的 探讨阿立哌唑联合认知行为疗法治疗精神分裂症的临床疗效.方法 将102例精神分裂症患者采用随机数字表法分为两组,每组51例.两组均给予阿立哌唑治疗,观察组联合认知行为疗法治疗,观察12周.比较两组临床疗效及治疗前后两组简明精神病评定量表、阳性症状评定量表、阴性症状评定量表评分结果 ,比较威斯康辛卡片评分.结果 观察组治疗总有效率为94.1％,对照组为72.5％,观察组显著高于对照组(P＜0.01).治疗后两组简明精神病评定量表、阳性症状评定量表、阴性症状评定量表评分均显著低于治疗前(P＜0.01),观察组较对照组下降更显著(P＜0.01).观察组威斯康辛卡片评分显著优于对照组(P＜0.01).结论 阿立哌唑联合认知行为疗法精神分裂症能有效提高患者的临床疗效,缓解阳性及阴性症状,改善认知功能,提高生活质量.“,”Objective To investigate the clinical effect of aripiprazole combined with cognitive behavioral therapy in the treatment of schizophrenia. Methods 102 patients with schizophrenia were randomly divided into two groups, 51 cases in each group. The two groups were all given aripiprazole treatment, and the observation group was plus cognitive behavioral therapy, patients were observed for 12 weeks. Clinical effect and BPRS,SAPS, SANS, WCST scores before and after treatment of the two groups were compared. Results Total effective rate of the observation group (94.1％) was significantly higher than that of the control group (72.5％) (P＜0.01). After treatment, BPRS, SAPS, SANS scores of the two groups were all significantly lower than those before treatment (P＜0.01),and the observation group declined more significantly than the control group (P＜0.01). WCST score of the observation group was significantly better than that of the control group (P＜0.01). Conclusions Aripiprazole combined with cognitive behavioral therapy in the treatment of schizophrenia can effectively improve the clinical effect of patients, relieve the positive and negative symptoms, improve cognitive function and life quality.