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本实验观察了氟化钠(NaF)急性中毒后的一段时间内小白鼠肠系膜微血管对作为交感神经兴奋递质的去甲肾上腺素(NE)收缩反应性的改变,以加深对NaF中毒后的肠微循环损伤机理的认识。 用半数致死量的NaF经胃给空腹小白鼠染毒,然后分别在染毒后半小时及1.5～60小时内用1‰及1％浓度的NE直接灌注小白鼠肠系膜,动态观察肠系膜细动脉、细静脉内径大小的变化,同时与未染毒但给予同样二种浓度的NE肠系膜灌注的对照组动物(为染毒半小时动物的自身前后实验对照;染毒1.5～60小时动物的实验对照)肠系膜细动脉、细静脉内径大小变化作比较。结果发现,二种浓度NE灌注肠系膜,染毒半小时动物的细动脉、细静脉对此二种浓度NE的收缩反应性与自身前后对照组动物相比无显著差异,染毒1.5～60小时动物细动脉、细静脉对这二种浓度NE仍有明显收缩反应性;但均低于相应的正常实验对照组。同时,这种降低了的收缩反应性与细血管种类及NE浓度有关,即二种细血管对1％NE的收缩反应性大于对1‰NE的收缩反应性,细静脉对1‰NE的收缩反应性大于细动脉对1‰NE的收缩反应性。
This experiment observed sodium fluoride (NaF) acute poisoning within a period of time after the mouse mesentery microvascular as sympathetic excitatory neurotransmitter norepinephrine (NE) contractile response changes in order to deepen the NaF poisoning after the intestine Cognition of microcirculation injury mechanism. Rats were drenched with half lethal dose of NaF to the stomach of fasting mice, then mesentery was directly perfused with 1 ‰ and 1% NE for half an hour and 1.5-60 hours respectively. The mesenteric arteries were observed dynamically. The changes of the inner diameter of the small veins, meanwhile, were compared with those of the control group of NE mesenteric perfusion group that were not exposed to the same two concentrations of NE (the control before and after exposure to animals for half an hour; the experimental control for animals exposed to 1.5 to 60 hours) Mesenteric arterioles, small vein diameter changes for comparison. The results showed that there was no significant difference in the contractile response of NE and NE before and after administration of two concentrations of NE to mesentery and half an hour of exposure to arterioles and venules in both concentration and concentration groups. Animals exposed to NE for 1.5 to 60 hours Fine arteries and veins still showed significant contractile response to these two concentrations of NE, but both were lower than the corresponding normal experimental control group. At the same time, this decreased contractile response was related to the type of blood vessel and the concentration of NE, ie, the contractile response of the two kinds of blood vessels to 1% NE was greater than that to 1 ‰ NE and that of the fine veins to 1 ‰ NE The reactivity is greater than that of the arteriole to 1 ‰ NE.