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CD47与抑制性受体信号调节蛋白a(SIRPa)可以形成CD47-SIRPa信号复合体,并具有介导双向调节信号以及调控多种免疫反应进程的作用。该信号复合物在免疫系统应答,巨噬细胞吞噬,中枢神经系统发育以及定向造血干细胞移植等方面都发挥了积极的作用。随着对CD47-SIRPa信号通路在免疫和中枢神经系统中作用机制越来越深入的研究,其成果也为自身免疫性疾病和神经系统疾病的治疗方面提供了更多新的治疗靶点。
CD47 and inhibitory receptor signal regulatory protein a (SIRPa) can form CD47-SIRPa signaling complexes, and have the role of mediating bidirectional regulatory signals and regulating the progression of multiple immune responses. The signaling complex plays an active role in immune system response, macrophage phagocytosis, central nervous system development, and targeted hematopoietic stem cell transplantation. As studies on the mechanism of action of the CD47-SIRPa signaling pathway in the immune and central nervous system become more and more in depth, the results provide more new therapeutic targets for the treatment of autoimmune diseases and neurological diseases.