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目的:观察加味温胆汤联合氨氯地平片对高血压(痰湿体质)疗效及对血管内皮生长因子(VEGF)的影响。方法:将134例痰湿体质高血压患者,随机分为研究组和对照组。对照组口服苯磺酸氨氯地平片治疗;研究组在对照组治疗基础上,服用加味温胆汤治疗。疗程12周。对比2组治疗前后血压变化,检测VEGF水平。结果:总有效率研究组97.01%,对照组71.64%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组血压均有改善,与本组治疗前比较,差异有统计学意义(P<0.05)。治疗后研究组血压改善更明显,与对照组比较,差异有统计学意义(P<0.05)。2组治疗后血清VEGF水平均有下降,研究组治疗后与治疗前比较,差异有统计学意义(P<0.05)。治疗后研究组与对照组比较,差异有统计学意义(P<0.05)。结论:加味温胆汤联合氨氯地平片对痰湿体质高血压临床疗效显著,并对VEGF有积极的影响,值得临床推广应用。
Objective: To observe the therapeutic effect of Jiaweimintan Decoction combined with amlodipine on hypertension (phlegm constitution) and its effect on vascular endothelial growth factor (VEGF). Methods: 134 cases of sputum wet constitutional hypertension were randomly divided into study group and control group. Control group oral amlodipine besylate tablets treatment; the study group in the control group based on the treatment, taking Jia Wei Wendan treatment. Treatment for 12 weeks. The changes of blood pressure in two groups before and after treatment were compared to detect the level of VEGF. Results: The total effective rate was 97.01% in the study group and 71.64% in the control group. There was significant difference between the two groups (P <0.05). After treatment, blood pressure in both groups improved, compared with the group before treatment, the difference was statistically significant (P <0.05). After treatment, the improvement of blood pressure was more obvious in the study group, and the difference was statistically significant (P <0.05) compared with the control group. Serum VEGF levels decreased in both groups after treatment, and the difference was statistically significant (P <0.05) between the two groups after treatment. After treatment, the study group and the control group, the difference was statistically significant (P <0.05). Conclusion: Modified Wendan Decoction combined with amlodipine has significant clinical effect on phlegm - dampness constitutional hypertension and has a positive effect on VEGF, which is worthy of clinical application.