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目的:观察大蒜素对青年女子足球运动员一次性大强度运动前后不同时相血清cTnI和CK-MBmass的影响。方法:青年女子足球运动员12名,随机分为对照组(n=6)和实验组(n=6)。对照组每天口服安慰剂80 mg,实验组每天口服大蒜素肠溶胶丸80 mg,2周后两组进行一次性大强度跑台运动,记录运动时间、跑动距离和运动中的最大心率。分别测定2周服药前和运动后4小时受试者血cTnI和CK-MBmass水平。结果:(1)两组运动员运动时间、运动距离和运动时最大心率的结果符合大强度运动的负荷特点,但两组间相比较差异无统计学意义。(2)运动后4小时两组血清cTnI较实验前均显著增加(P<0.05),实验组运动后4小时血清cTnI浓度显著低于对照组(P<0.05)。(3)运动后4小时两组血清CK-MBmass较实验前均降低,但无统计学意义,组间亦无显著性差异。结论:一次性大强度运动后青年女子足球运动员血清cTnI均显著增加,提示大强度运动导致心肌微损伤。实验组运动员血清cTnI低于对照组,提示大蒜素对减轻运动性心肌微损伤具有积极作用。
Objective: To observe the effects of allicin on serum cTnI and CK-MBmass in young female soccer players before and after one-time intensive exercise. Methods: Twelve young female football players were randomly divided into control group (n = 6) and experimental group (n = 6). The control group was orally given placebo 80 mg daily. The experimental group was orally administered 80 mg of allicin enteric-coated capsules daily. Two weeks later, the two groups were given one-time high-intensity treadmill exercise. The exercise time, the running distance and the maximum heart rate during exercise were recorded. The levels of cTnI and CK-MBmass in blood of the subjects were measured before treatment and 4 hours after exercise respectively. Results: (1) The results of exercise time, exercise distance and maximal heart rate of athletes in both groups accorded with the load characteristics of intensive exercise, but there was no significant difference between the two groups. (2) Serum cTnI of both groups increased significantly (P <0.05) 4 hours after exercise, and serum cTnI concentration of experimental group 4 hours after exercise was significantly lower than that of control group (P <0.05). (3) CK-MBmass in serum of two groups decreased after 4 hours of exercise, but there was no statistical significance. There was no significant difference between groups. Conclusion: The serum cTnI of young female soccer players increased significantly after one-time high intensity exercise, suggesting that intensive exercise resulted in myocardial micro-injury. Experimental group athletes cTnI lower than the control group, suggesting allicin to reduce myocardial motility myocardial injury has a positive effect.