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本文采用特异性化学损毁技术及钾离子透入法测痛,观察了用5.6-双羟色胺(5.6—DHT)破坏了大鼠巨细胞网状核(NGC)和中缝大核(NRM)内5—羟色胺(5—HT)神经元后痛阈的变化。结果表明:NGC 内注射5.6—DHT 后,第4、6、8天痛阈较基础痛阈显著下降。NRM 内注射5.6—DHT 后,第4、6、8和16天痛阈较注射前均有显著下降,且痛阈下降幅度大,恢复过程长。提示:NGC 或NRM内5—HT 神经元均参与痛觉的下行调制,而NRM 内5—HT 神经元在镇痛中可能处于主要地位。本文并对NGC 和NRM 内5—HT 神经元在痛觉调制中的相互关系进行了分析。
In this paper, specific chemical damage technique and potassium iontophoresis were used to measure the pain. It was observed that 5.6-DHT destroyed the expression of 5- Changes in pain threshold of serotonin (5-HT) neurons. The results showed that after 5.6-DHT was injected into NGC, the pain threshold on the 4th, 6th and 8th days was significantly lower than the baseline pain threshold. After 5.6-DHT was injected into NRM, the pain thresholds on the 4th, 6th, 8th and 16th days were significantly decreased compared with that before injection, and the pain threshold decreased greatly and the recovery process was long. It is suggested that 5-HT neurons in NGC or NRM are all involved in downregulation of pain sensation, while 5-HT neurons in NRM may play a dominant role in analgesia. This article also analyzes the relationship between 5-HT neurons in pain modulation in NGC and NRM.