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目的:观察曲尼司特对大鼠急性心肌梗死(AMI)后心肌纤维化和左室功能的影响。方法:结扎大鼠 冠状动脉制成AMI模型,随机分成假手术组(6只)、AMI组(8只)、曲尼司特组(7只)和苯那普利组(6只)。于 第4周末,用放射免疫法测定血浆和心肌血管紧张素Ⅱ含量,用氯胺T法测定羟脯氨酸含量,动脉插管测定大鼠 左室心功能。结果:与AMI组比较,曲尼司特不能降低血浆和心肌血管紧张素Ⅱ水平,但能减少非梗死区心肌羟 脯氨酸含量,降低左室舒张末压,升高±dp/dt。结论:曲尼司特可减轻AMI后左室心肌纤维化,改善左室功能。
Objective: To observe the effect of tranilast on myocardial fibrosis and left ventricular function after acute myocardial infarction (AMI) in rats. Methods: The AMI model was established by ligating the coronary arteries of rats. The rats were randomly divided into sham operation group (n = 6), AMI group (n = 8), tranilast group (7) and benazepril group (n = 6). At the end of the fourth week, plasma and myocardial angiotensin Ⅱ levels were determined by radioimmunoassay. Hydroxyproline content was measured by chloramine T method and left ventricular function was measured by arterial cannulation. Results: Tranilast decreased plasma and myocardial angiotensin Ⅱ levels compared with AMI group, but decreased myocardial hydroxyproline content, decreased left ventricular end-diastolic pressure and increased ± dp / dt in non-infarcted area. Conclusion: Tranilast reduces left ventricular myocardial fibrosis and improves left ventricular function after AMI.