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目的:研究和探讨不同剂量米非司酮治疗子宫肌瘤的临床疗效。方法:选取我院收治的80例子宫肌瘤患者为研究对象,均给予米非司酮治疗,按用药剂量不同分为观察组(40例,小剂量米非司酮治疗),对照组(40例,大剂量米非司酮治疗),对比两组患者的治疗效果。结果:两组患者闭经发生率、血红蛋白水平比较,差异无统计学意义(P>0.05);观察组患者治疗后的子宫肌瘤体积、子宫体积及p、E2、LH、FSH等激素水平、不良反应总发生率均显著低于对照组,差异有统计学意义(P<0.05)。结论:不同剂量米非司酮治疗子宫肌瘤,均有明显作用,但小剂量米非司酮安全性较高,可有效缩小子宫肌瘤及子宫体积,降低激素水平、不良反应发生率,疗效更加确切。
Objective: To study and explore the clinical efficacy of different doses of mifepristone in the treatment of uterine fibroids. Methods: Eighty patients with uterine fibroids admitted to our hospital were enrolled in this study. All patients were treated with mifepristone. The patients were divided into observation group (40 cases, low dose mifepristone group) and control group (40 cases) Cases, high-dose mifepristone treatment), compared the treatment effect of two groups of patients. Results: The incidence of amenorrhea and hemoglobin in the two groups had no significant difference (P> 0.05). The volume of uterine fibroids, uterine volume, hormone levels of p, E2, LH and FSH, The total incidence of the reaction was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion: Different doses of mifepristone treatment of uterine fibroids have a significant effect, but low-dose mifepristone high safety, can effectively reduce the uterine fibroids and uterine volume, reduce hormone levels, the incidence of adverse reactions, the effect More accurate.