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目的探讨胰岛素样生长因子1(Insulin-like growthfactor1,IGF-1)、胰岛素抵抗程度与前列腺体积的相关性。方法收集我院老年病科良性前列腺增生症(benign prostatic hyperplasia,BPH)患者90例,根据下尿路症状(lower urinary tract symptoms,LUTS)、国际前列腺症状评分(international prostate symptoms score,IPSS)、前列腺特异性抗原(prostate specific antigen,PSA)以及经腹超声前列腺体积测定分为观察组和对照组。观察组有下尿路症状且IPSS为中重度症状并确诊为BPH,对照组没有下尿路症状。收集这些患者的一般资料和生化特征。结果与对照组相比,观察组的空腹血糖(FBG)[(6.29±0.77)vs(4.77±0.33)mmol/L]、空腹胰岛素(FINS)[(12.92±3.81)vs(8.49±2.04)mU/L]、胰岛素抵抗指数(HOMA-IR)[(3.60±1.27)vs(1.89±0.36)]、低密度脂蛋白(LDL-c)[(3.74±0.37)vs(2.05±0.48)mmol/L]水平较高(P<0.05),而IGF-1[(104.63±26.14)vs(169.78±53.70)μg/L]与高密度脂蛋白(HDL-c)[(1.12±0.20)vs(1.75±0.21)mmol/L]水平较低(P<0.01)。结论 IGF-1、胰岛素抵抗与前列腺增生的程度有关,是BPH发生、发展的危险因素。
Objective To investigate the relationship between insulin-like growth factor 1 (IGF-1), insulin resistance and prostate volume. Methods Ninety patients with benign prostatic hyperplasia (BPH) in our hospital were collected. According to the lower urinary tract symptoms (LUTS), the international prostate symptoms score (IPSS), the prostate Specific antigen (prostate specific antigen, PSA) and transabdominal sonography were divided into observation group and control group. Observation group had lower urinary tract symptoms and IPSS was moderate and severe symptoms and diagnosed as BPH, the control group without lower urinary tract symptoms. Collect general information and biochemical characteristics of these patients. Results Compared with the control group, the fasting blood glucose (FBG) [(6.29 ± 0.77) vs (4.77 ± 0.33) mmol / L], FINS (12.92 ± 3.81) vs (8.49 ± 2.04) mU / L], HOMA-IR [(3.60 ± 1.27) vs (1.89 ± 0.36) vs LDL-c [3.74 ± 0.37 vs 2.05 ± 0.48 mmol / L (1.12 ± 0.20) vs (1.75 ± 0.06) vs high density lipoprotein (HDL-c) [(104.63 ± 26.14 vs 169.78 ± 53.70 μg / 0.21) mmol / L] (P <0.01). Conclusion IGF-1, insulin resistance is related to the degree of benign prostatic hyperplasia and is a risk factor for the occurrence and development of BPH.