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用分光光度法研究了替米沙坦与氯冉酸的电荷转移反应条件,替米沙坦与氯冉酸在丙酮溶液中可以发生电荷转移反应,在室温下按实验方法配好溶液即可比色。电荷转移络合物的最大吸收波长是525nm,表观摩尔吸光系数为2.18×10~2L·mol~(-1)·cm~(-1)。替米沙坦质量浓度在16—192mg·L~(-1)范围内服从比耳定律,相关系数为0.9997。当替米沙坦浓度为80mg·L~(-1)时,六次测定结果的相对标准偏差为1.33%,回收率在99.0%以上。测得荷移络合物的组成和稳定常数分别为1:2和3.9×10~7。用于测定制剂中替米沙坦的含量结果令人满意。
The charge transfer reaction conditions of telmisartan and chloranilic acid were studied by spectrophotometry. The telmisartan and chlorambucil acid charge-transfer reaction can occur in acetone solution, and at room temperature by experimental method with a good solution can be colorimetric . The maximum absorption wavelength of the charge - transfer complex was 525 nm, and the apparent molar absorptivity was 2.18 × 10 -2 L · mol -1 (-1) cm -1. The concentration of telmisartan obeys Beer’s law in the range of 16-192 mg · L -1 with a correlation coefficient of 0.9997. When the concentration of telmisartan was 80 mg · L -1, the relative standard deviation (RSD) of six determinations was 1.33% and the recovery was above 99.0%. The composition and the stability constants of the charged complex were measured as 1: 2 and 3.9 × 10-7, respectively. The results for the determination of telmisartan in the formulation are satisfactory.