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作者应用放免方法测定8例肝硬化顽固性腹水病人血浆心钠素水平变化,并对心钠素水平与尿钠关系进行初步分析。结果表明,①肝硬化顽固性腹水组(RA)血浆心钠素水平(99±48pg/ml)与正常对照组(102±40pg/ml)比较虽无明显差异(q=0.2,P>0.05),但较肝硬化非顽固性腹水组(NRA,176±32pg/ml)已有显著降低(q=5.1,P<0.01)。②NRA组尿钠与血浆心钠素水平呈明显正相关(r=0.67,P<0.05),但于RA组则否,二者无明显相关(r=-0.11,P>0.05)。提示,肝硬化晚期血浆心钠素水平降低及利钠效应衰败可能系顽固性腹水形成的一个重要因素。
The authors applied radioimmunoassay method to determine plasma atrial natriuretic peptide levels in 8 patients with cirrhosis and refractory ascites and analyzed the relationship between atrial natriuretic peptide level and urinary sodium. The results showed that there was no significant difference (q = 0.2, P> 0.05) between plasma atrial natriuretic peptide level of 99 ± 48 pg / ml and 102 ± 40 pg / ml of cirrhosis patients with refractory ascites (RA) , But was significantly lower than that of cirrhotic non-refractory ascites group (176 ± 32pg / ml) (q = 5.1, P <0.01). ② There was a significant positive correlation between urinary sodium and plasma atrial natriuretic peptide in NRA group (r = 0.67, P <0.05), but not in RA group (r = -0.11, P> 0.05). Tip, advanced cirrhosis of plasma atrial natriuretic peptide level and the decline of sodium effect may be refractory ascites formation is an important factor.