外源性化学物质(包括药物、化学毒物和食品中的化学杂质)对机体的作用与作用持续时间,在很大程度上取决于体内的代谢情况。转化这些化学物质的脏器主要是肝,近年来,由于亚细胞生物化学的进展,认识到肝细胞赖以进行生物转化的亚细胞结构主要为内质网(肝细胞磨成匀浆并离心后,内质网破裂形成小囊,称微粒体)的酶系,后者的活性对外源性化学物质的转化途径及速度等皆有重大影响,从而使其毒性与毒作用方式发生显著变化。因而深 Exogenous chemicals (including drugs, chemical poisons and chemical impurities in food) on the body’s role and duration of action, largely depends on the body’s metabolism. In recent years, due to the progress of the subcellular biochemistry, it has been recognized that the subcellular structure by which the hepatocytes undergo biotransformation is mainly the endoplasmic reticulum (after the liver cells are homogenized and centrifuged , The formation of endoplasmic reticulum rupture vesicles, known as microsomes) enzyme system, the latter activity on the exogenous chemical conversion pathway and speed have a significant impact, so that the toxicity and toxic effects of significant changes. So deep