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目的观察红霉素治疗婴幼儿重症急性毛细支气管炎(SACB)的疗效。方法 SACB患儿50例分为两组:B组20例,常规治疗;A组30例,加用红霉素治疗。另选择正常健康婴幼儿20例为对照(C)组。观察A、B组临床症状改善及住院时间。ELISA法检测三组血清IL-8和可溶性血管细胞间黏附分子1(sVCAM-1)水平。结果A组临床症状持续时间及住院时间均短于B组(P<0.05)。疾病恢复期,A、B组血清IL-8和SVCAM-1水平均低于急性期(P<0.01和P<0.05),A组低于B组(P<0.05)。结论在常规治疗基础上加用红霉素治疗婴幼儿SACB可明显抑制细胞因子和黏附分子产生,改善临床症状。
Objective To observe the efficacy of erythromycin in the treatment of infant severe acute bronchiolitis (SACB). Methods Fifty children with SACB were divided into two groups: group B, 20 cases, routine treatment; group A, 30 cases, plus erythromycin. Another 20 cases of normal healthy infants and young children as a control group (C). A, B group to observe the clinical symptoms and hospital stay. Serum levels of IL-8 and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured by ELISA. Results The duration of clinical symptoms and hospital stay in group A were shorter than that in group B (P <0.05). The levels of serum IL-8 and SVCAM-1 in group A and group B were lower than those in acute phase (P <0.01 and P <0.05), and group A was lower than group B (P <0.05). Conclusion The addition of erythromycin to infants SACB on the basis of routine treatment can significantly inhibit the production of cytokines and adhesion molecules and improve the clinical symptoms.