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目的 探讨米非司酮对子宫肌瘤超微结构的作用。方法 随机选择子宫肌瘤患者 2 4例 ,连续服用米非司酮 2 5mg或 12 5mg ,12周后行子宫切除术 ,取子宫标本 ,在电镜下观察肌瘤超微结构变化。并随机选择 6例未用药的子宫肌瘤患者 ,同样方法取标本进行比较。结果 米非司酮可使肌瘤细胞及血管不同程度的退行性改变。结论 米非司酮可用于子宫肌瘤的治疗
Objective To investigate the effect of mifepristone on the ultrastructure of uterine fibroids. Methods Twenty-four patients with uterine leiomyoma were randomly selected and treated with 25 mg or 125 mg of mifepristone continuously. Hysterectomy was performed 12 weeks later. Uterine specimens were collected and the ultrastructural changes of fibroids were observed under electron microscope. And randomly selected 6 patients without uterine fibroids patients, the same method to take specimens for comparison. Results Mifepristone fibroids and blood vessels can make varying degrees of degenerative changes. Conclusion Mifepristone can be used for the treatment of uterine fibroids