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目的:探讨中药复方肝心宁(GXN)胶囊抗实验性肝纤维化(HF)的疗效及作用机理。方法:以四氯化碳(CCI4)复合因素制作大鼠HF模型,并给予GXN灌胃治疗,同时设秋水仙碱(COL)、大黄虫丸(DHZCP)作为对照。观察经GXN治疗对大鼠肝脏指数、脾脏指数、血清透明质酸酶(HA)、板层素(LN)、IV型胶原(C-IV)、Ⅲ型前胶原(PCⅢ)及病理形态学的影响。结果:本药有一定的回缩肝脾作用;能降低血清HA、LN、C-IV、PCⅢ等HF指标。结论:提示本药有良好的抗HF作用。
OBJECTIVE: To investigate the efficacy and mechanism of GXN capsules in the treatment of experimental hepatic fibrosis (HF). METHODS: Rat HF models were prepared with carbon tetrachloride (CCI4) complex and GXN was given intragastrically. Colchicine (COL) and rhubarb schistosome (DHZCP) were also used as controls. Observed liver index, spleen index, serum hyaluronidase (HA), laminin (LN), type IV collagen (C-IV), type III procollagen (PCIII) and pathological morphology of rats treated with GXN influences. Results: The drug has a certain degree of retraction of liver and spleen; can reduce serum HA, LN, C-IV, PCIII and other HF indicators. Conclusion: It is suggested that the drug has good anti-HF effect.