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目的观察时辰化疗联合调强放疗与常规化疗联合调强放疗对局部晚期鼻咽癌患者生命质量和营养状况的影响。方法将85例局部晚期鼻咽癌患者随机分为试验组42例和对照组43例。试验组诱导化疗及同步化疗时在固定时间采用时辰化疗,对照组采用常规化疗,同步放疗均采用调强放疗。采用EORTC QLQ-C30、QLQ-H&N35、NRS 2002和PG-SGA量表观察两组患者治疗前后生命质量和营养状况的变化。结果诱导化疗后试验组患者总健康状况评分明显高于对照组(P<0.05);恶心呕吐、食欲丧失、便秘、吞咽困难和体重增加等症状领域得分低于对照组(P<0.05);同步放化疗结束后,试验组患者在总健康状况、降低恶心呕吐等领域得分明显优于对照组,差异有统计学意义(P<0.05)。NRS 2002与PG-SGA量表评估结果显示,两组患者治疗结束后发生营养不良例数明显增加,对照组增加病例数多于试验组。结论同步放化疗治疗局部晚期鼻咽癌患者采用时辰化疗,恶心呕吐、总体健康状况及生命质量均优于常规化疗,可能是更合理的治疗模式。
Objective To observe the effect of time chemotherapy combined with intensity modulated radiotherapy and conventional chemotherapy combined with intensity modulated radiotherapy on the quality of life and nutritional status of patients with locally advanced nasopharyngeal carcinoma. Methods Eighty-five patients with locally advanced nasopharyngeal carcinoma were randomly divided into experimental group (42 cases) and control group (43 cases). The experimental group chemotherapy and synchronous chemotherapy in a fixed time using hour chemotherapy, the control group using conventional chemotherapy, synchronous radiotherapy are used to intensity modulated radiotherapy. The changes of the quality of life and nutritional status of the two groups before and after treatment were observed with EORTC QLQ-C30, QLQ-H & N35, NRS 2002 and PG-SGA scales. Results After the induction chemotherapy, the scores of the total health status of the experimental group were significantly higher than those of the control group (P <0.05). The scores of symptoms such as nausea, vomiting, loss of appetite, constipation, dysphagia and weight gain were lower than those of the control group (P <0.05) After the end of chemoradiotherapy, the test group patients in the overall health status, reduce nausea and vomiting and other fields was significantly better than the control group, the difference was statistically significant (P <0.05). NRS 2002 and PG-SGA scale assessment showed that the number of malnutrition cases in both groups increased significantly after treatment, and the number of cases in the control group increased more than that in the experimental group. Conclusions Simultaneous chemoradiotherapy is superior to conventional chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma with hourly chemotherapy, nausea and vomiting, general health and quality of life, which may be a more reasonable treatment mode.