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目的 对PVP方案术前诱导化疗治疗口腔鳞癌的近期疗效及安全性进行评价。方法 16例口腔鳞癌,均采用PVP方案化疗即CDDP 100mg/m~2)+VCR 2mg+PYM 80mg,化疗结束后第10天,手术前,按照国际通用标准,进行近期疗效的评定,对药物毒副作用进行观察。结果 治疗口腔鳞癌16例,近期有效率(缓解率)为93.75％。化疗的主要毒副作用为呕吐、脱发、骨髓抑制等。结论 以大剂量顺铂为主的联合化疗(PVP)方案,术前诱导化疗的近期疗效显著,在晚期口腔鳞癌的综合治疗中可推广应用,化疗中严格执行水化和利尿的原则,可提高化疗的安全性。
Objective To evaluate the short-term efficacy and safety of PVP regimen in the induction of chemotherapy for oral squamous cell carcinoma (OSCC). Methods Twenty-six patients with oral squamous cell carcinoma were treated with PVP regimen (CDDP 100 mg / m ~ 2) + VCR 2 mg + PYM 80 mg. Ten days after the chemotherapy, before surgery, the curative effect was evaluated according to the international standard. Toxic side effects were observed. Results The treatment of oral squamous cell carcinoma in 16 cases, the recent effective rate (response rate) was 93.75%. The main side effects of chemotherapy for vomiting, hair loss, bone marrow suppression. Conclusions The high-dose cisplatin-based combination chemotherapy (PVP) regimen is effective in preoperative induction chemotherapy. It can be widely used in the treatment of advanced oral squamous cell carcinoma. The principle of hydration and diuresis should be strictly implemented in chemotherapy. Improve the safety of chemotherapy.