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目的观察西格列汀治疗2型糖尿病的效果。方法选取医院收治的2型糖尿病患者156例作为研究对象,随机分为对照组和观察组,每组78例。2组均给予饮食和运动治疗,对照组采用盐酸二甲双胍片治疗;观察组采用西格列汀治疗。观察比较2组治疗前后血糖水平,治疗后尿微量蛋白、C反应蛋白及还原型谷胱甘肽水平的变化情况。结果 2组治疗前FBG、2hPBG、HbA1c的水平无明显差异,但治疗后观察组的治疗效果明显优于对照组(P<0.05);通过对比2组治疗后的尿微量蛋白、C反应蛋白及还原型谷胱甘肽水平的变化情况,观察组的治疗水平明显优于对照组(P<0.05)。结论西格列汀治疗2型糖尿病能有效缓解和控制血糖水平,值得临床推广应用。
Objective To observe the effect of sitagliptin on type 2 diabetes. Methods A total of 156 patients with type 2 diabetes treated in our hospital were selected as study subjects and randomly divided into control group and observation group with 78 cases in each group. 2 groups were given diet and exercise therapy, the control group treated with metformin hydrochloride tablets; observation group treated with sitagliptin. The changes of blood glucose level, urine microalbumin, C-reactive protein and glutathione level were observed and compared between the two groups before and after treatment. Results There was no significant difference in FBG, 2hPBG and HbA1c levels between the two groups before treatment, but the therapeutic effect of the observation group was significantly better than that of the control group (P <0.05). After comparing the urine microalbumin, C-reactive protein and Reduced glutathione levels in the observation group were significantly better than the control group (P <0.05). Conclusion Sitagliptin treatment of type 2 diabetes can effectively alleviate and control blood glucose levels, worthy of clinical promotion and application.