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目的探讨2型糖尿病心脏自主神经病变筛查方法以及相关危险因素。方法 36例2型糖尿病患者作为观察组,36例糖耐量正常者作为对照组,均进行口服葡萄糖耐量试验(OGTT)和胰岛素释放等试验,对两组心脏自主神经病变的患病率及各生化检验指标进行对比分析。结果观察组心脏自主神经病变患病率55.56%高于对照组5.56%(P<0.05)。观察组空腹胰岛素、尿酸和血肌酐水平(113.42±96.41)pmol/L、(398.54±94.21)μmol/L、(77.54±32.14)μmol/L均显著高于对照组(61.36±41.84)pmol/L、(324.24±110.36)μmol/L、(62.35±18.35)μmol/L(P<0.05)。结论 2型糖尿病患者易患心脏自主神经病变,空腹胰岛素、尿酸和血肌酐水平升高是2型糖尿病心脏自主神经病变的危险因素,需要采取措施进行防治。
Objective To investigate the screening methods and related risk factors of cardiac autonomic neuropathy in type 2 diabetic patients. Methods Twenty-six patients with type 2 diabetes mellitus (T2DM) as observation group and 36 patients with normal glucose tolerance as control group were given oral glucose tolerance test (OGTT) and insulin release test. The prevalence of cardiac autonomic neuropathy and biochemical Test indicators for comparative analysis. Results The prevalence of cardiac autonomic neuropathy in observation group was 55.56% higher than that in control group (5.56%, P <0.05). The levels of fasting insulin, uric acid and serum creatinine (113.42 ± 96.41) pmol / L and (398.54 ± 94.21) μmol / L and (77.54 ± 32.14) μmol / L in the observation group were significantly higher than those in the control group (61.36 ± 41.84 pmol / L , (324.24 ± 110.36) μmol / L and (62.35 ± 18.35) μmol / L respectively (P <0.05). Conclusions Patients with type 2 diabetes are predisposed to cardiac autonomic neuropathy. Increased fasting insulin, uric acid and serum creatinine are risk factors for cardiac autonomic neuropathy in type 2 diabetic patients. Measures need to be taken to control them.