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目的探讨2型糖尿病患者甲状腺结节的发病率及相关影响因素。方法回顾性分析内蒙古呼伦贝尔地区3 200例行甲状腺结节超声筛查的2型糖尿病住院患者的临床资料,收集患者的年龄、性别、身高、体质量指数(BMI)、胰岛素抵抗指数(HOMA-IR)及病程等相关因素进行单因素、多因素分析。结果 2型糖尿病患者中共检出甲状腺结节患者1 984例(62.0%)。单因素分析示性别、年龄及HOMA-IR是2型糖尿病患者甲状腺结节的危险因素(P<0.05)。Logstic多因素回归分析示性别(OR=0.324,95%CI=0.221~0.698)、年龄(OR=1.117,95%CI=1.021~1.365)及HOMA-IR(OR=1.364,95%CI=1.112~1.569)均与2型糖尿病患者甲状腺结节发病相关(P均<0.05),女性、高龄及高HOMA-IR是2型糖尿病患者甲状腺结节的独立危险因素。结论 2型糖尿病患者具有较高的甲状腺结节发病率,女性、高龄及高HOMA-IR是2型糖尿病患者甲状腺结节的独立危险因素。
Objective To investigate the incidence and related factors of thyroid nodules in type 2 diabetic patients. Methods The clinical data of 3 200 inpatients with type 2 diabetes who were screened by thyroid nodules under ultrasound in Hulunbeier, Inner Mongolia were retrospectively analyzed. The age, sex, height, body mass index (BMI), insulin resistance index ) And course of disease and other related factors single factor, multivariate analysis. Results A total of 1 984 cases (62.0%) of thyroid nodules were detected in type 2 diabetic patients. Univariate analysis showed that sex, age and HOMA-IR were risk factors for thyroid nodules in type 2 diabetic patients (P <0.05). Logistic multivariate regression analysis showed that the odds ratio (OR = 0.324, 95% CI = 0.221-0.698), age (OR = 1.117, 95% CI = 1.021-1.365) and HOMA-IR 1.569) were all associated with the onset of thyroid nodules in type 2 diabetic patients (all P <0.05). Female, elderly and high HOMA-IR were independent risk factors for thyroid nodules in type 2 diabetic patients. Conclusion The incidence of thyroid nodules in type 2 diabetic patients is high. Female, elderly and high HOMA-IR are independent risk factors for thyroid nodules in type 2 diabetic patients.