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凋亡抑制因子(inhibitor of apoptosis proteins,IAPs)是一类高度保守的内源性抗细胞凋亡因子家族,主要通过抑制Caspase活性和参与调节核因子NF-κB的作用而抑制细胞凋亡。细胞抗凋亡机制在肿瘤发生、发展以及肿瘤耐药性形成中发挥重要作用。肿瘤细胞高表达IAPs是导致肿瘤细胞抵抗凋亡的关键。细胞凋亡调控异常与肿瘤细胞耐药密切相关,增强肿瘤细胞对化疗药物的敏感性成为近年来肿瘤治疗的重要策略之一。该文综述了IAP家族蛋白的结构、生物学特性及其作为肿瘤治疗靶点的研究进展。
Inhibitors of apoptosis proteins (IAPs) are a type of highly conserved family of endogenous anti-apoptotic factors that inhibit apoptosis primarily by inhibiting Caspase activity and by participating in the regulation of the nuclear factor NF-κB. Cell anti-apoptotic mechanisms play an important role in tumorigenesis, development and tumor drug resistance formation. High expression of IAPs in tumor cells is the key factor that leads to tumor cells to resist apoptosis. The abnormal regulation of apoptosis is closely related to the resistance of tumor cells. Increasing the sensitivity of tumor cells to chemotherapeutic drugs has become one of the important strategies in cancer treatment in recent years. This review summarizes the structural, biological properties of IAP family proteins and their advances as targets for cancer therapy.