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目的 :探讨女性尿毒症患者卵巢功能障碍的发病情况及其临床意义。方法 :应用酶免疫法 (EIA)测定了2 3例更年期前女性尿毒症非透析患者、15例透析患者及 2 9例健康献血者中促卵泡素 (FSH)、泌乳素 (PRL)、促黄体素 (LH)、雌二醇 (E2 )及孕酮 (P)的水平。结果 :尿毒症女患者PRL、FSH及LH均较健康对照组升高 ,而孕酮值显著降低 ,对此均有显著差异 ;且尿毒症女患者PRL升高、孕酮值降低与肾小球滤过率 (GFR)呈明显相关。透析患者较非透析患者PRL升高更为明显 ,孕酮值亦较非透析患者有所升高 ,但无显著意义。结论 :尿毒症女患者的排卵障碍及月经紊乱等都与尿毒症的严重程度相平行。透析并不能改善尿毒症女患者的卵巢功能障碍 ,只有纠正与改善肾功能 ,才能使尿毒症女患者的卵巢功能得以改善
Objective: To investigate the incidence of ovarian dysfunction in women with uremia and its clinical significance. Methods: Serum levels of follicle stimulating hormone (FSH), prolactin (PRL), luteinizing hormone (PRL) and progesterone in 23 dialysis patients and 29 healthy blood donors were measured by enzyme immunoassay (EIA) LH), estradiol (E2) and progesterone (P) levels. Results: The levels of PRL, FSH and LH in female patients with uremia were higher than those in healthy controls, while the values of progesterone were significantly lower in female patients with uremia. There was a significant increase in PRL, decreased progesterone, Filtration rate (GFR) was significantly correlated. Dialysis patients than non-dialysis patients PRL increased more significantly, progesterone values than non-dialysis patients increased, but no significant significance. Conclusion: Uremic female patients with ovulation disorders and menstrual disorders, etc. are in parallel with the severity of uremia. Dialysis does not improve ovarian dysfunction in women with uremia, and ovarian function can be improved only by correcting and improving renal function