论文部分内容阅读
目的研究选择性肠道去污(SDD)对小儿MODS的防治效果。方法2004年4月~2005年6月在ICU住院的符合MODS诊断的患儿60名,随机分成常规治疗组M1组(30名),常规治疗+口服庆大治疗(SDD)M2组(30名),分析研究治疗前、后两组患儿的血清炎症介质的变化、并发症的发生率和病死率。结果M1组在ICU的平均住院时间为(14.68±4.8)d,M2组为(9.69±1.56)d,(P<0.05);M1组出现感染并发症的人数多于M2组;M2组患儿中性粒细胞计数在治疗期间下降更为明显;M1组患儿血清TNF浓度在治疗前、后没有显著变化,M2组血清TNF浓度在治疗后明显降低。结论选择性肠道去污的治疗能有效减轻并发症,缩短病程,能否降低病死率有待进一步探讨。
Objective To study the effect of selective intestinal decontamination (SDD) on the prevention and treatment of MODS in children. Methods Sixty children with MODS who were hospitalized in ICU from April 2004 to June 2005 were randomly divided into M1 group (30), conventional treatment + oral dexamethasone (SDD) group M2 (30 ), To analyze the changes of serum inflammatory mediators, complication rates and mortality of the two groups before and after treatment. Results The average duration of hospital stay in the ICU was (14.68 ± 4.8) days in the M1 group and (9.69 ± 1.56) days in the M2 group (P <0.05). The incidence of complications in the M1 group was more than that in the M2 group Neutrophil count decreased more significantly during treatment; serum TNF concentrations in children with M1 group before and after treatment did not change significantly, M2 serum TNF concentration decreased significantly after treatment. Conclusion The treatment of selective intestinal decontamination can effectively reduce complications, shorten the course of the disease, reduce the mortality need to be further explored.