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放线菌素“23—21”现定名为更新霉素。一九六五年前我们曾做过放线菌素23—21的一些药理实验。近年来除了妇科用于恶性葡萄胎和绒毛膜上皮癌的治疗,收到较好的效果外,还试用于急淋和慢淋急性变的治疗,初步取得缓解之效。为了协助临床使用这一新药时选择合适的剂量,达到较高的疗效和减低毒性的目的,根据协作的要求,我们再用12只狗观察给更新霉素(福州制药厂生产,批号750818)前后其周围血象、肝肾功能、心电图及一般活动的变化,并对中毒死亡和处死的狗进行病理检查。现将结果报告如下。
Actinomycin “23-21” is now named as an updated doxorubicin. We had done some pharmacological experiments of actinomycin 23-21 before 1965. In recent years, in addition to gynecology for the treatment of malignant mole and choriocarcinoma, received good results, but also for the treatment of acute lymphocytic and chronic lymphocytic change, the initial effect of mitigation. In order to assist the clinical use of this new drug to select the appropriate dose to achieve a higher efficacy and reduce toxicity, according to the requirements of collaboration, we then use 12 dogs observed to do not have the virus (Fuzhou Pharmaceutical Factory production, batch number 750818) before and after The surrounding blood, liver and kidney function, ECG and general changes in activity, and died of poisoning and executed dogs for pathological examination. The results reported below.