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前列腺增生(BPH)除可以引起膀胱颈梗阻症状以外,还可继发逼尿肌不稳定,约75%的病人可出现膀胱刺激症状,前列腺内增生的组织可为腺体成份,但主要是平滑肌等间质,内含丰富的α_1受体,在其作用下可引起下泌尿系动力性梗阻,用α_1受体阻滞剂能松弛前列腺尿道周围的平滑肌,改善梗阻症状,Chapple对这一问题进行了临床研究,他对93例血压正常的BPH病人(最大尿流率均小于15ml秒)用同样方案分别在两个医疗中心进行治疗,随机分为两组:A组服哌唑嗪0.5mg一日二次共4天,然后增加到1mg一日二次共4天,最后改为2mg一日二次,一直服12周,B组则服安慰剂作为对照,采用
Prostate hyperplasia (BPH) in addition to can cause symptoms of bladder neck obstruction, but also secondary to detrusor instability, about 75% of patients may have bladder irritation, prostate gland hyperplasia tissue components can be, but mainly smooth muscle Interstitial, containing a rich α_1 receptors, in its role can cause lower urinary tract obstruction, with α_1 receptor blockers can relax the smooth muscle around the prostatic urethra to improve obstruction symptoms, Chapple on this issue In a clinical study of 93 patients with normotensive BPH (maximal uroflow rates less than 15 ml sec) were treated in the same centers in two separate centers and randomly assigned to two groups: group A received prazosin 0.5 mg Day for a total of four days, and then increased to 1mg twice daily for 4 days, finally changed to 2mg twice a day, has been serving for 12 weeks, B group taking placebo as control, using