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目的：探讨肺动脉高压（ＰＨ）对左心室舒张功能（ＬＶＤＦ）的影响及其发生机理。方法：用彩色多普勒超声心动图结合右心导管检测观察２８例继发有ＰＨ先心病（ＣＨＤ）病人的ＬＶＤＦ，并与２０例无ＰＨ的ＣＨＤ病人对比分析。结果：继发有ＰＨ的病人二尖瓣口血流频谱Ａ峰流速（ＡＶ）、速度时间积分（ＡＶＩ）较对照组明显增高（Ｐ＜０．０５～０．０１），Ｅ峰流速（ＥＶ）、速度时间积分（ＥＶＩ）无明显改变（Ｐ＞０．０５），ＡＶ／ＥＶ、ＡＶＩ／ＥＶＩ增大（Ｐ＜０．０１），左室等容舒张期（ＬＩＶＲＴ）延长（Ｐ＜０．０５），且肺动脉压与ＡＶ／ＥＶ比值成中等相关（ｒ＝０．４１８９～０．４２４６，Ｐ＜０．０１）。结论：ＰＨ可致ＬＶＤＦ减退，并推测其机理可能与ＰＨ所引起的室间隔运动异常、肥厚、两室间充盈的相互影响及左室三维几何形态的改变等因素有关。
Objective: To investigate the effect of pulmonary hypertension (PH) on left ventricular diastolic function (LVDF) and its mechanism. Methods: The color Doppler echocardiography combined with right heart catheterization was used to detect the LVDF in 28 patients with PHD secondary to CHD, and compared with 20 CHD patients without PH. Results: A peak velocity (AV) and velocity time integral (AVI) of mitral flow in secondary PH patients were significantly higher than those in control group (P <0.05 ~ 0.01) (P <0.05), AV / EV and AVI / EVI increased (P <0.01), LIVRT prolonged .05). Pulmonary arterial pressure was moderately correlated with AV / EV ratio (r = 0.4189-0.4246, P <0.01). CONCLUSION: PH can lead to the decrease of LVDF, and it is speculated that the mechanism may be related to the abnormalities of ventricular septum caused by PH, hypertrophy, the interaction between two chambers and the change of left ventricular three-dimensional geometry.